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A departure from the swirls on this page, I was inspired by some illuminated manuscripts and did a simple flowering vine.
The vine was sketched out first and then the flowers were added. The vine is done with a gold metallic pen, the flowers outlined in regular ball point pen and colored with prismacolor pencil. I usually sketch lightly in pencil before going over it with anything else. That way any mistakes can easily be erased.
These are my tools of choice. A good pencil (the finer the better), a Pentel Clic Eraser (because it's white and lasts a long time), and my first choice in a pen, any color you like of Pilot BP-S Fine. This one is blue, they have black, red, greed, and have had purple also. This pen gives a nice clean, thin line which is especially good for making notes in the margins.
I usually worked on these pages during church and so needed to be quiet. I made a roll up pencil holder out of fabric and elastic that worked well for many years.
There's this one I found through Pinterest made of felt and it is very similar.